"Reported
cash equivalents and marketable securities of $92.1 million, which the
Company believes will be sufficient to meet estimated working capital
requirements and fund planned program development
into 2014."
"Preliminary
results from the Company’s randomized Phase 2b study suggest that CDX-011
induces impressive response rates compared to current, available therapies
in patients with advanced, refractory breast cancers."
Overview
Celldex Therapeutics (CLDX)
is the first antibody-based combination immunotherapy company. Celldex has a
pipeline of drug candidates in development for the treatment of cancer and
other difficult-to-treat diseases based on its antibody focused Precision
Targeted Immunotherapy (PTI) Platform. The PTI Platform is a complementary
portfolio of monoclonal antibodies, antibody-targeted vaccines and
immunomodulators used in optimal combinations to create novel
disease-specific drug candidates.
CLDX
Investor Highlights
Announced
preliminary results from the Company’s randomized Phase 2b study of CDX-011 (glembatumumab vedotin) antibody drug conjugate in
patients with glycoprotein NMB (GPNMB) expressing, advanced, heavily
pretreated breast cancer. Preliminary results suggest that CDX-011
induces impressive response rates compared to current, available
therapies in patients with advanced, refractory breast cancers with high
GPNMB expression (expression in ≥25% of tumor cells).
Announced that the Company
will be added to the NASDAQ
Biotechnology Index® (NBI),
effective prior to market open on Monday, May 21, 2012.
Reported cash equivalents
and marketable securities of $92.1 million, which the Company believes
will be sufficient to meet estimated working capital requirements and
fund planned program development
into 2014, including enrollment of both the pivotal ACT IV study and the
ReACT Phase 2 study for rindopepimut (CDX-110).
Anthony
S. Marucci - Founder, President, Chief Executive Officer, and Director
Mr. Marucci is a Founder of Celldex and
served as its Vice President, Chief Financial Officer, Treasurer and
Secretary since inception and prior to his appointments to Executive Vice
President in March 2008, President and Chief Executive Officer in October
2008, and the Board of Directors in December 2008. Celldex, founded in 2004
as a subsidiary of Medarex (Medarex is now a wholly-owned subsidiary of
Bristol Myers Squibb), was initially spun out as an independent private
company in October 2005 with the asset acquisition of CDX-110 from Alteris
Therapeutics, Inc. and the acquisition of Lorantis Limited (Cambridge, UK).
In addition to these acquisitions, Mr. Marucci is also responsible for the
AVANT Immunotherapeutics, Inc. and Celldex Therapeutics, Inc. merger
completed during the first quarter of 2008 and the acquisition of CuraGen
Corporation completed in the third quarter of 2009. He was Treasurer of
Medarex from December 1998 to March 2004, where he held a series of senior
financial positions since December 1998. He is a member of the Board of
Trustees of BioNJ and also served as its Treasurer through 2010. Mr. Marucci
received his B.S. in Accounting from Kean University and his M.B.A. from
Columbia University.
Avery
W. Catlin - Vice President, Chief Financial Officer and Secretary
Mr. Catlin joined Celldex in January 2000 as
Senior Vice President and Chief Financial Officer. He also serves as
Secretary. Prior to joining Celldex, he served as Vice President, Operations
and Finance, and Chief Financial Officer of Endogen, Inc., a public life
science research products company, from 1996 to 1999. From 1992 to 1996, he
held various financial positions at Repligen Corporation, a public
biopharmaceutical company, serving the last two years as Chief Financial
Officer. Earlier in his career, he held the position of Chief Financial
Officer at MediSense, Inc., a Massachusetts-based medical device company.
Mr. Catlin received his B.A. degree from the University of Virginia and
M.B.A. from Babson College and is a Certified Public Accountant.
Tibor
Keler, Ph.D. - Founder, Vice President and Chief Scientific Officer
Dr. Keler is a founder of Celldex and served
as its Vice President of Research and Discovery since inception and prior to
his appointment to Senior Vice President and Chief Scientific Officer in
March 2008. Celldex, founded in 2004 as a subsidiary of Medarex (Medarex is
now a wholly-owned subsidiary of Bristol Myers Squibb), was initially spun
out as an independent private company in October 2005 with the asset
acquisition of CDX-110 from Alteris Therapeutics, Inc. and the acquisition
of Lorantis Limited (Cambridge, UK). Previously, Dr. Keler was Senior
Director of Preclinical Development and Principal Scientist at Medarex from
September 1993 to March 2004. While at Medarex, he was responsible for the
preclinical development of a number of Medarex clinical product candidates.
In addition, Dr. Keler was responsible for the development of Celldex's core
technology and related products. Dr. Keler received his Ph.D. in
Microbiology from the University of Pennsylvania.
119 Fourth Avenue
Needham, MA 02494
Phone: 781-433-0771
Fax: 781-433-0262
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